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Pharmacology and Toxicology of Leflunomide
Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...
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ژورنال
عنوان ژورنال: Japanese Journal of Pesticide Science
سال: 2013
ISSN: 2187-0365,2187-8692
DOI: 10.1584/jpestics.w12-34